[Wlug] MySQL replication question

Does anyone have experience with MySQL's replication capabilities? I'm running versions 4.1.8 and 4.1.14 servers on linux and windows, and I have a very remote site where I'd like to support replication. The data changes very slowly, but the link has 300 ms (ping) latency and has a small (but noticeable) amount of down time. Does it work well enough to be considered reliable for critical applications? TIA, Bill